Cell adhesion is a complex process since it underlies the self-organization of cells in multicellular organisms. We study how cell-matrix adhesion sites (Fig. 1) are assembled, regulated and function. Fundamental challenges for understanding these processes arise from the large number of adhesion site components and the complex interactions between them (Fig. 2). To comprehensively cope with this complexity, we develop diverse imaging and systems biology approaches. By applying these approaches for different cellular contexts, we gain insights about principles governing cell-matrix adhesion.
|Figure 1. Cell-matrix adhesion sites. Cell-matrix adhesion is mediated by dynamic and diverse sites along the plasma membrane at which transmembrane receptors of the integrin family anchor the actin cytoskeleton to components of the extracellular matrix via a multi-protein structure. The scheme is modified from Hoffmann et al., eLife 3:e02257 (2014).|
© 2017 Eli Zamir, www.cell-adhesion.com